Browsing by Subject "Antimicrobial"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    Embargo
    Assessment of antimicrobial activity of coffee brewed in three different ways from different origins
    (Springer, 2011-07-29) Martínez-Tomé, Magdalena; Jiménez-Monreal, Antonia M.; García-Jiménez, Laura; Almela, Luis; García-Diz, Luis; Mariscal-Arcas, Miguel; Murcia, M. Antonia
    The antimicrobial effect against pathogens such as Staphylococcus aureus, Enterecoccus faecalis, Listeria monocytogenes, Pseudomonas aeruginosa, Escherichia coli and Salmonella choleraesius was determined in four types of coffee (Coffea arabica L. cv. Colombia, decaffeinated cv. Colombia, cv. Ethiopia and cv. Kenya). Coffee was seen to have significant activity against the growth of food spoilage bacteria. Among the Gram-positive bacteria, coffee was strongly active against S. aureus, moderately active against L. monocytogenes and had a slightly inhibitory effect against E. faecalis. However, coffee samples were found to be less active against Gram-negative bacteria. The results show that espresso Colombia coffee has better antimicrobial activity than filter and Italian coffee with significant differences (p\0.05). Taking into account the origin, there were significant differences (p\0.05) between Kenya and decaffeinated Colombia, on the one hand, and Ethiopia and Colombia coffee, on the other, the two last showing the highest antimicrobial activity. The antimicrobial activity of the coffee from different origins studied in this paper increased with concentration. Typical coffee compounds were also analysed, and only caffeic and chlorogenic acids showed any inhibitory effect against the growth of all the analysed bacteria. The antibacterial properties of coffee means that it has a promising potential as natural food ingredient to extend the shelf life of foods such as cake, cookies or biscuits, coffee flavoured with shakes, yoghurt.
  • Thumbnail Image
    Publication
    Open Access
    El poder antimicrobiano de las especias.
    (Comunidad Autónoma de la Región de Murcia, Consejería de Educación y Cultura, Servicio de Publicaciones., 2024) Cánovas Guasch, Marta; Sánchez Villa, Fuensanta
    En el presente trabajo se ha investigado el efecto antimicrobiano de las especias clavo y canela sobre un alimento de consumo frecuente en la población como es el arroz cocido. Para realizar este estudio, se ha llevado a cabo un análisis cualitativo de muestras de arroz cocido a las que se han añadido las especias clavo, canela o mezcla de las anteriores; enteras o molidas, a temperatura ambiente y en refrigeración, realizando una comparativa con muestras control que únicamente contenían el alimento. Se han obtenido los siguientes resultados: el clavo y la canela, ambas molidas, retardan la aparición de hongos en las muestras, con un efecto más prolongado respecto a la acción del clavo entero y la canela en rama. La refrigeración aumenta la acción antimicrobiana de todas las especias. La conclusión general ha sido que el clavo presenta un efecto antimicrobiano mucho mayor que la canela.
  • Thumbnail Image
    Publication
    Open Access
    Therapeutic potential of pteridine derivatives: a comprehensive review
    (Wiley, 2018-10-19) Carmona‐Martínez, Violeta; Vera, María; Guirado, Antonio; García-Peñarrubia, Pilar; Martínez-Esparza Alvargonzález, María Concepción; Ruiz Alcaraz, Antonio José; Bioquímica y Biología Molecular B e Inmunología
    Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or immune system activation molecules. This variety of biological functions has motivated the synthesis of a huge number of pteridine derivatives with the aim of studying their therapeutic potential. This review gathers the state‐of‐the‐art of pteridine derivatives, describing their biological activities and molecular targets. The antitumor activity of pteridine‐based compounds is one of the most studied and advanced therapeutic potentials, for which several molecular targets have been identified. Nevertheless, pteridines are also considered as very promising therapeutics for the treatment of chronic inflammation‐related diseases. On the other hand, many pteridine derivatives have been tested for antimicrobial activities but, although some of them resulted to be active in preliminary assays, a deeper research is needed in this area. Moreover, pteridines may be of use in the treatment of many other diseases, such as diabetes, osteoporosis, ischemia, or neurodegeneration, among others. Thus, the diversity of the biological activities shown by these compounds highlights the promising therapeutic use of pteridine derivatives. Indeed, methotrexate, pralatrexate, and triamterene are Food and Drug Administration approved pteridines, while many others are currently under study in clinical trials.