Histology and histopathology Vol.16, nº 4 (2001)

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Browsing Histology and histopathology Vol.16, nº 4 (2001) by Subject "Angiogenesis"

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    Arterial wall neovascularization induced by glycerol
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2001) Díaz Flores, L.; Gutierrez, R.; Valladares, F.; Díaz, M.; Valera, H.; Díaz Flores Jr, L.; Madrid Cuevas, Juan Francisco
    An int e nse a nd sig ni fica nt neo - vascul ari za tion, with numerous capillaries growing into th e med ia laye r o f th e rat femo ra l art e ry, was demonstrated when glycero l was administered into the interstitium be tween the femoral ve in and the femoral a rt e ry. Th e max imum mi c rovasc ul a ri za ti o n was obse rved at days 7 and 9 after glyce rol administration. Afterwards, invo lution of th e majo rit y of the new lyfo rmed microvessels in the art erial wall occurred. Other substances containing glyce rol in their molecul es, such as tri ace tyl-glyce rol and tri butyril-glyce rol, fa il ed to produce significant neovascul ari zation in the medi a laye r of the femora l art ery. Neova cul ariza tion of the art eri al wa ll was preceded by a co nside rab le dec rease in the number of the smooth muscle ce lls, whi ch ex perienced apoptosis and necrobiosis, disappearing in extense areas of the arteri al segment affected by glyce rol. Coinciding with neovascul ariza tion and mi crovascul ar in volu tion, repopul ation of the med ia laye r by smooth mu 'cle cells was observed.
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    Recent progress in T-cadherin (CDH13, H-cadherin) research
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2001) Takeuchi, T.; Ohtsuki, Y.
    T-cadherin is a un ique cadherin ce ll ad hesion molecul e that is anchored to the ce ll surface membrane th rough a glycosy l phosphat id yl inositol (G PI) moiety. The cy topl asmic domain , whi ch T-cad herin lacks. is be li eved to bc criti ca l fo r homophilic binding th ro ugh int erac ti on with subm cmbran e cy tos ke letal protc in s. Docs this mea n th at T- ca dh e rin is an un imp ortanl molec ul e? Howcvc r, th e T-cadherin amino ac id moti f has bee n we ll co nse rve d thro ug h evo luti o n in ve rt ebr ates, s uggestin g th a t T-c adh e rin may have biologica l signifi ca nce in higher animals. Co nsistent wi th this hypothesis, recent studies have thrown light on the re levance of T-cadh erin in the fie lds of oncology, neurology, respirology and ca rdiovascular ph ysiology. In this manu sc ript , we rev iew current adva nces in Tcad herin research.