(Murcia : F. Hernández, 1994) Yamanouchi, J.; Yasoshima, A.; Han, J.S.; Itagaki, S.; Doi, K.
Electron microscopic observations
were carried out on the spontaneous glomerular lesions
in male APA hamsters from 3 to 12 months of age.
Until 6 months of age, focal expansion of mesangial
region due to an increase of matrix material and
mesangial cells was characteristic, and segmental
thickening of capillary basement membrane and partial
effacement of foot processes of podocytes were also
sometimes observed. At 12 months of age, although
al1 of these changes became more severe, the most
prominent alteration was found in podocytes, which
showed various degenerative changes. No deposition
of amyloid fibrils was detected in any portion of
the glomerulus.