(Murcia : F. Hernández, 2000) Andres-Barquin, P.J.; Hernandez, M.C.; Israel, M.A.
Id genes encode helix-loop-helix proteins
that function to mediate processes important for normal
development including cellular differentiation.
proliferation and apoptosis. Id proteins act as negative
regulators of other transcription factors, which are
essential for cell determination and differentiation in
diverse cell types, and interact with proteins important
for cell cycle regulation. Studies of Id gene expression in
the nervous system and in neural cells in culture indicate
that Id proteins contribute to the regulation of
mammalian nervous system development. Also,
recognition of a wide variety of proteins with which Id
transcription factors are capable of interacting suggests
that it will be possible to understand more precisely their
specific functions and importantly how these are
integrated.